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Why Anecdotes Are Unreliable Placebo effect : Expecting improvement creates real perceived improvement Selection bias : People who feel better are more likely to report Regression to the mean : Injuries often improve on their own Confounding variables : Diet, rest, other treatments No verification : Claims can’t be independently confirmed Why Anecdotes Still Matter Anecdotal reports aren’t worthless—they generate hypotheses worth testing

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On the one hand, α-Syn is involved in mediating mitochondrial fragmentation independently of Drp1