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Copper(II) ions form coordination complexes with the imidazole nitrogen of histidine and the amino terminal amine of glycine

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HCA’s anticancer effects are mediated through multiple signaling pathways, including NF-κB, extracellular signal-regulated kinase (ERK), protein kinase C, calcium signaling, phosphatidylinositol 3-kinase (PI3K) and nuclear transcription activity [163,164]