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The nine tissue systems now documented in the preclinical literature were not predicted by computational models or receptor-binding assays at the outset — they were identified sequentially as researchers in different laboratories independently tested the compound against different experimental injury models and consistently found meaningful effects

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[1] Tirzepatide acts through two incretin receptors at once , GIP and GLP-1, adding a glucose-dependent insulin-secretion effect that an amylin analog does not have