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Thus, the scarce human studies performed so far, regardless of all of the limitations in some of them (i.e., they lacked a large sample size, ethnic variation, and a sham control group), encompassed a wide range of investigations (i.e., ulcerative colitis [65], knee pain [263], and interstitial cystitis [264])

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The Federal Trade Commission (FTC) has also pursued actions against companies making unsubstantiated health claims about peptide and collagen products, particularly in the direct-to-consumer market