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No interactions were found between GPx-1 genotypes and selenium levels in this population, although in males, the lowest quartile of serum selenium associated with the lowest level of GPx-1 activity by unadjusted linear regression analysis

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Under physiological conditions, the BBB serves as a critical interface composed of endothelial cells connected by tight junction proteins, pericytes, and surrounding glial elements regulating the transport of molecules to the central nervous system